抄録
1-Methyl-3-di (2-thienyl) methylenepiperidine citrate (AT-327) showed antitussive effect more potent than codeine in unanesthetized dogs and effect approximately equal to codeine in pentobarbitalized cats. The efficacy was also demonstrated in clinical trials with 45 patients. The antitussive activity seemed to be due to its direct action on the cough center per se. The drug did not show any analgesic activity, tendency of establishing tolerance, or indicate addiction liability, either in animal experiments or in clinical trials. The toxicity was found to be lower than that of codeine in the mouse. Other pharmacological properties of the drug were also discussed briefly.
