Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Researches on Chemotherapeutic Drugs against Viruses. XXX. Synthesis and Antiviral Activity of 2-Dimethylaminoethyl Alkylbenzhydryl Ether.
村岡 全子伊藤 知男水間 豊治豊島 滋
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1960 年 8 巻 10 号 p. 860-866

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Compounds of 2-dimethylaminoethyl p-alkylbenzhydryl ether and p, p'-dialkylbenzbydryl ether series were synthesized and their activity was examined using the Nakayama strain of Japanese B encephalitis and the PR-8 strain of influenza A virus. p, p'-Dipropyl-, p, p'-dibutyl, and p, p'-dibutyl derivatives were found to have considerable activity on the PR-8 strain in membrane culture, and p-dodecyl derivative was recognized to be effective on the Japanese B encephalitis virus in mice.
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© The Pharmaceutical Society of Japan
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