Effect of Amino Alcohols and their Phosphoryl Compounds on the Growth of Experimentally Transplantable Cancer.

Abstract

Effect of 2-aminoethanol, 2-methylaminoethanol, 2-dimethylaminoethanol, choline, and their phosphorylated compounds on the growth of Ehrlich solid tumor and in vitro growth of Yoshida sarcoma cells was examined and following facts were revealed. 1) On the Ehrlich tumor, 2-aminoethyl dihydrogenphosphate and 2-methylaminoethyl dihydrogenphosphate had a growth-promoting effect while the others had no effect. 2) 2-Aminoethanol and 2-aminoethyl dihydrogenphosphate were inhibitive to the in vitro growth of Yoshida sarcoma cells but others had no effect. 3) There was entirely no difference in the lipids between the groups administered and not administered 2-aminoethyl dihydrogenphosphate.