Abstract
N-Methyl[14C]-bis(2-chloroethyl)amine N-oxide (14C-labeled nitrogen mustard N-oxide) was synthesized for pharmacological and biochemical experiments using Methyl-[14C]iodide. Its specific activity was determined as 6, 500 counts/min./μmole by Q-gas flow counter. The labeled compound was given to a dog intravenously and the urine was taken out from the opened bladder. Concentration of the compound in the urine was quantitatively determined by radioactivity measurement.
