Studies on Carcinostatic Substances. XXIV. Preparation of Diphenylphosphoric Acid Esters of N-Methyl-and N-Phenyl-bis(2-hydroxyethyl)amine and their Alkylating Activity.

Abstract

Bis(diphenylphosphate) of N-emthyl- and N-phenyl-bis(2-hyproxyethyl)amine was proved to have alkylating activity against mercapto group of L-cysteine and thiosulfate in a neutral aqueous solution. The compounds exhibited only a slight anti-tuomr cytological effect on Yoshida sarcoma in vitro and in vivo.