Metabolism of Drugs. XXII. The Metabolic Fate of Thiamylal. (1)

Abstract

Thiamylal was orally administered to rabbits and its metabolites excreted in urine were examined, mainly by paper chromatography. One of the metabolites was isolated and characterized as a carboxylic acid with thiobarbituric acid ring and allyl side-chain. Comparing the paper chromatogram of urine of rabbits receiving thiamylal or secobarbital, it was apparent that thiamylal was metabolized to the compounds not only with thiobarbituric acid ring and its oxygen homologs but also without the ring structure.