Syntheses of Pyridazine Derivatives. V. Nitration of 3-Methoxypyridazine 1-Oxide

Abstract

Nitration of 3-methoxypyridazine 1-oxide (I) afforded 3-methoxy-4-nitropyridazine 1-oxide (II) and 3-methoxy-4, 6-dinitropyridazine 1-oxide, showing that the positions ortho and para to the N-oxide group are reactive to electrophilic substitution.