Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Metabolic Fate of 1-Ethynylcyclohexyl Carbamate. I. Metabolic Products in the Urine of Humans and Rabbit receiving 1-Ethynylcyclohexyl Carbamate
Toshiro Murata
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1960 Volume 8 Issue 7 Pages 629-633

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Abstract
Paper chromatography was carried out on the urine of rabbits and men receiving 1-ethynylcyclohexyl carbamate. The chromatogram revealed the presence of six spots by the Tollens reagent and three of them were assumed to be the metabolites, degradation products of the carbamate. One of them was identified as the hydroxylated ethynylcyclohexyl carbamate which was also obtained by extraction of the urine of man receiving 1-ethynylcyclohexyl carbamate. Another spot on the chromatogram was assumed to be that of a conjugated form of the metabolite such as the glucuronide which had been reported by McMahon.
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© The Pharmaceutical Society of Japan
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