Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Cinnoline Chemistry. VIII. α-(ω-Dialkylaminoalkyl)-α-phenyl-4-cinnolineacetonitriles and Related Compounds.
/ 恩田 政行Masayuki Onda
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1961 年 9 巻 12 号 p. 1008-1011

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Five new (ω-dialkylaminoalkyl) phenylacetonitriles were prepared and these and other similar nitriles were condensed with 4-chlorocinnoline in the presence of sodium amide to produce seven new α-(ω-dialkylaminoalkyl)-α-phenyl-4-cinnolineacetonitriles. All of these condensed nitriles were hydrolyzed and decarboxylated to seven new 4-[(1-phenyl-ω-dialkylamino) alkyl] cinnolines. These latter two classess of compounds were prepared for pharmacological screening.
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© The Pharmaceutical Society of Japan
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