Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Studies on the Synthetic Analgesics. XVI. Synthesis of 1-(2-tert-Aminoalkyl)-3, 4-dihydrocarbostyrils.
Noboru Shigematsu
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1961 Volume 9 Issue 12 Pages 970-975

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Abstract
As a part of studies on nonnarcotic antipyretic-analgesic, 1-(2-tert-aminoalkyl)-3, 4-dihydrocarbostyril (III : R'=H), 1-(2-tert-aminoalkyl)-6-hydroxy-3, 4-dihydrocarbostyril (III : R'=6-OH), and 1-(2-tert-aminoalkyl)-7-hydroxy-3, 4-dihydrocarbostyril (III : R'=7-OH) were synthesized. Analgesic, antitussive, and antipyretic action of these compounds were examined and some of these compounds showed anticipated activity.
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© The Pharmaceutical Society of Japan
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