Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Organic Phosphates. XV. Synthesis and Alcoholysis Reaction of 4, 4'-Dinitro-hydrobenzoin Cyclic Phosphate.
浮田 忠之進竹下 隆三
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1961 年 9 巻 8 号 p. 600-606

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4, 4'-Dinitrohydrobenzoin cyclic phosphate was synthesized. Alcoholysis reaction of this compound with various hydroxylic compounds in acid or alkaline medium was found to occur to a greater extent than a similar reaction for non-substituted hydrobenzoin cyclic phosphates. Thus, the new cyclic phosphate was alcoholyzed with polyols such as DL-erythritol and D-mannitol, which were found to be inert to the non-substituted hydrobenzoin cyclic phosphate. The mode of the hydrolysis reaction of methyl 4, 4'-dinitrohydrobenzoin phosphate, an intermediate product of methanolysis of 4, 4'-dinitrohydrobenzoin cyclic phosphate, in acid and alkaline media was found to be different from that of methyl hydrobenzoin phosphate.
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© The Pharmaceutical Society of Japan
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