Cell Structure and Function
Online ISSN : 1347-3700
Print ISSN : 0386-7196
ISSN-L : 0386-7196
Lex Structure Enhances Myocardial Differentiation from Embryonic Stem Cells
Akiharu SudouHisako MuramatsuTadashi KanameKenji KadomatsuTakashi Muramatsu
著者情報
ジャーナル フリー

1997 年 22 巻 2 号 p. 247-251

詳細
抄録
α-1, 3-Fucosyltransferase (Fuc TIV) cDNA was placed under the control of β-actin, cytomegalovirus enhancer/promoter and transfected into embryonic stem cells. The transfected cell clones with integrated cDNA (positive clones) differentiated more efficiently into myocardial cells than the clones without integrated cDNA (negative clones) or parental cells. Furthermore, myocardial cells differentiated from the positive clones survived longer than those differentiated from the negative clones or parental cells. These results indicate that Lewis X structure, the product of Fuc T IV, enhances myocardial differentiation. The mechanism of the phenomenon is discussed in relation to integrin action.
著者関連情報
© Japan Society for Cell Biology
前の記事 次の記事
feedback
Top