抄録
ABSTRACT. Human and rabbit fibroblasts showed marked phagocytic activity for latex particles coated with human IgG when they were incubated at 37°C in vitro. After 24 to 48 hours of incubation the intracellular acid phosphatase activity increased and release of the enzyme was stimulated. A strong histochemical reaction of acid phosphatase was observed in the cell cytoplasm under a light microscope. Electron microscopy showed that the reaction was localised in the secondary lysosomes, especially in the dense reaction products around the IgG-coated latex particles. The intensity of the acid phosphatase reaction was higher in latex-phagocytized cells than in the non phagocytic controls. This indicates that the activity of acid phosphatase, a typical lysomal enzymes, is stimulated in fibroblasts by phagocytosis as it is in neutrophils and macrophages.
