核酸を用いた人工的リガンド

—ランダムシェイプライブラリーからの選択—

抄録

Recently, a great advance has been achieved in creating bioactive molecules using combinatorial selection from a shape library. The library which contains a large number of molecular variants are prepared at the start of the selection, then a subset of the library is selected to bind a target molecule on the basis of shape. This library can include polymers consisting of natural or modified amino acids, nucleotides, carbohydrates and other organic materials. Directing molecular evolution in the test tube, this selection strategy would be useful to elucidate natural molecular interaction and to create novel bioactive molecules. Here, principles and applications of this method were described to create artificial ligands composed of DNA and RNA.