Drug Delivery System
Online ISSN : 1881-2732
Print ISSN : 0913-5006
ISSN-L : 0913-5006
Lipo-PGE1投与膠原病患者におけるサーモグラフィの検討
本多 佐保今井 浩三青木 繁雄渥美 進一光内 正樹石田 禎夫辻崎 正幸近藤 吉宏日野田 裕治谷内 昭
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1991 年 6 巻 5 号 p. 387-393

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Peripheral circulation of the fingers were analyzed by use of thermography in eight patients with PSS and MCTD. Skin temperature of the fingers in those patients was lower than that in controls. Recovery after exposure of the chilled water in the fingers of the patients tended to be much delayed than in those of controls. Patterns of the recovery of the temperature in the fingers were different between patients with severe damage of peripheral circulation and controls : the former was recovered from the paroximal part to distal part, whereas the latter was recovered from the tips of the finger. Raynaud's phenomenon, pain as well as the ulcer of the tips of the fingers were recovered after infusion of lipo-PGE1. Thermography examination revealed that the duration of the effect of lipo-PGE1, is 2-3 hours. It is speculated that the administration of lipo-PGE1 might be useful for preventing fingers from the severe damage due to vascultis.
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