皮膚科学と分子生物学

抄録

During the past decade, molecular biological techniques have led to the discovery of the molecular basis of many genetic disorders of the skin. In addition, the sequencing of the genome was completed, and protein-coading regions were identified last year. This paper reviews the relationship between modern molecular biology and dermatology and focuses on single gene disorders, polygenic disorders, modifier genes, mosaicism, genotype-phenotype relationships, single nucleotide polymorphisms, DNA chip techniques, microarray techniques, and gene therapy. Molecular biological techniques will play increasingly important roles in clinical dermatology.