ATP-mediated Release of a DNA-binding Protein from a Silicon Nanoneedle Array

Daisuke MATSUMOTO; Maui NISHIO; Yoshio KATO; Wataru YOSHIDA; Koichi ABE; Kyoko FUKAZAWA; Kazuhiko ISHIHARA; Futoshi IWATA; Kazunori IKEBUKURO; Chikashi NAKAMURA

doi:10.5796/electrochemistry.84.305

コミュニケーション

ATP-mediated Release of a DNA-binding Protein from a Silicon Nanoneedle Array

Daisuke MATSUMOTO, Maui NISHIO, Yoshio KATO, Wataru YOSHIDA, Koichi ABE, Kyoko FUKAZAWA, Kazuhiko ISHIHARA, Futoshi IWATA, Kazunori IKEBUKURO, Chikashi NAKAMURA

著者情報

キーワード: Controlled Release, ATP Aptamer, Nanoneedle Array

ジャーナルフリー

2016 年 84 巻 5 号 p. 305-307

DOI https://doi.org/10.5796/electrochemistry.84.305

詳細

抄録

We describe a new method for delivering a zinc finger protein directly into cells using a nanoneedle array and an ATP aptamer. The zinc finger protein can be used for site-specific DNA modification by combining with an enzyme that can cut or modify DNA. This controlled release method utilizes aptamer conformational changes to deliver various biomolecules specifically into cells.

責任著者(Corresponding author)

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