Endocrine Journal
Online ISSN : 1348-4540
Print ISSN : 0918-8959
ISSN-L : 0918-8959

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TERT promoter mutations in thyroid cancer
Michiko MatsuseNorisato Mitsutake
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ジャーナル オープンアクセス 早期公開

論文ID: EJ23-0136

この記事には本公開記事があります。
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TERT promoter mutations (TERT-p mutations) have been found in many types of cancer and have emerged to play critical roles in tumor progression. The mutations upregulate TERT transcription, and TERT not only elongates telomeres and confers unlimited proliferative capacity on tumor cells, but is also involved in tumor progression and aggressiveness. In differentiated thyroid carcinoma, TERT-p mutations are associated with a number of high-risk clinicopathological aggressiveness and worse prognosis, making it the best molecular marker to predict tumor aggressiveness so far. This review summarizes recent relevant findings regarding TERT-p mutations and their functional/mechanistic aspects.

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© The Japan Endocrine Society

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https://creativecommons.org/licenses/by-nc-nd/4.0/deed.en
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