A prediction model of liver fat fraction and presence of non-alcoholic fatty liver disease (NAFLD) among patients with overweight or obesity

Jie Chen; Jiang Yue; Jingjing Fu; Shengyun He; Qianjing Liu; Minglan Yang; Wang Zhang; Hua Xu; Qing Lu; Jing Ma

doi:10.1507/endocrj.EJ23-0227

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A prediction model of liver fat fraction and presence of non-alcoholic fatty liver disease (NAFLD) among patients with overweight or obesity

Jie Chen ^†, Jiang Yue ^†, Jingjing Fu ^†, Shengyun He, Qianjing Liu, Minglan Yang, Wang Zhang, Hua Xu, Qing Lu , Jing Ma

著者情報

Jie Chen ^†
Department of Endocrinology and Metabolism, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China
Jiang Yue ^†
Department of Endocrinology and Metabolism, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China
Jingjing Fu ^†
Department of Endocrinology and Metabolism, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China
Shengyun He
Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China
Qianjing Liu
Department of Endocrinology and Metabolism, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China
Minglan Yang
Department of Endocrinology and Metabolism, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China
Wang Zhang
Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China
Hua Xu
Department of Endocrinology and Metabolism, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China
Qing Lu 責任著者
Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China
Jing Ma 責任著者
Department of Endocrinology and Metabolism, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China
著者の貢献

†Jie Chen, Jiang Yue, Jingjing Fuは本研究に等しく貢献した。

キーワード: Non-alcoholic fatty liver disease (NAFLD), Magnetic resonance imaging proton density fat fraction (MRI-PDFF), Obese, Overweight

ジャーナルオープンアクセス早期公開

論文ID: EJ23-0227

DOI https://doi.org/10.1507/endocrj.EJ23-0227

この記事には本公開記事があります。

The final version of this article is now available: Vol. 70 (2023), No. 10 pp. 977-985

詳細

抄録

The global prevalence of non-alcoholic fatty liver disease (NAFLD) has attained a level of 25.24%. The prevalence of NAFLD in China has exhibited an upward trajectory in parallel with the increasing incidence of obesity over the preceding decade. In order to comprehensively assess hepatic lipid deposition in individuals with overweight or obesity, we have devised a pioneering prognostic formula that capitalizes on clinical parameters. To this end, we have conducted a cross-sectional cohort study involving 149 overweight or obese subjects. Magnetic resonance imaging proton density fat fraction (MRI-PDFF) has been employed to evaluate the extent of liver fat accumulation. Through univariate analysis, we have identified potential factors, and the definitive elements in the prediction model were selected utilizing the forward stepwise regression algorithm. The Shang Hai Steatosis Index (SHSI) incorporates alanine aminotransferase (ALT), aspartate aminotransferase (AST), fasting insulin, and 1-h postload glycaemic levels, thereby furnishing the capability to predict NAFLD with an area under the receiver operator characteristic (AUROC) of 0.87. By establishing a threshold value of 10.96, determined through Youden’s index, we have achieved a sensitivity of 69.57% and a specificity of 88.24%. The Spearman correlation coefficient between liver fat fraction ascertained by MRI-PDFF and that predicted by the SHSI equation amounts to 0.74. Consequently, the SHSI equation affords a dependable means of predicting the presence of NAFLD and liver fat accumulation within the overweight and obese population.

責任著者(Corresponding author)

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