抄録
Capillary resistance, plasma and urinary pepsinogen, and urine volume were determined in eight healthy young males, when they were treated with saline (S), chlorpromazine (CP), adrenaline (A), noradrenaline (NA), CP+A, and CP+NA. The resuts were as follows:
1. S and CP did not affect capillary resistance, while both A and NA raised it twice with an intervening fall. The first rise with A was lost by combination with CP, whereas the first rise with NA was not lost by combination with CP. This fact implies strongly that A and NA act differently on the peripheral vascular system, and also that certain catabolites of A and NA might participate in the second rise in capillary resistance.
2. A increased uropepsin excretion, but NA decreased it. However, neither A nor NA had any influence upon plasma pepsinogen. CP checked and delayed the initial rise in uropepsin with A, but CP+NA increased it in contrast to the effect of NA administration alone. CP did not affect urinary pepinogen, while it greatly raised urine volume. Both A and NA apparently counteracted the diuretic action of CP, although A seemed more effective than NA in this measure.
