Endocrine Journal
Online ISSN : 1348-4540
Print ISSN : 0918-8959
ISSN-L : 0918-8959
Effect of Sustained Hyperglycemia on the Release of Insulin From the Isolated Perfused Rat Pancreas
KATSUHIKO WADAMAMORU KIMURAKENJI TAKAHASHIMAKOTO TOMINAGAHIDEO SASAKI
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1993 年 40 巻 2 号 p. 237-244

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The modulation of insulin release from the isolated pancreas using normal rats rendered hyperglycemic by in vivo glucose infusion was studied. In 24h and 48h hyperglycemic rats, the increase in the amount of insulin released was reduced in response to glucose challenge, but was unchanged in relation to arginine challenge. In 48h hyperglycemic rats insulin secretion after glucagon challenge was preserved. It was concluded that hyperglycemia itself makes the pancreatic B-cell selectively insensitive to glucose.

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© The Japan Endocrine Society
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