Unexplained Increase in Serum Corticosteroid-Binding Globulin Levels in a Patient with Chronic Thyroiditis, Pituitary Adenoma and Empty Sella

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Unexplained high serum corticosteroid-binding globulin (CBG) concentrations (mean±SD, 74.1±12.1μg/dl; normal women, 32.5±5.6μg/dl) were found in an unmarried woman who was not pregnant or taking exogenous estrogens. She was also found to suffer from subclinical chronic thyroiditis, pituitary adenoma and empty sella. The increased serum CBG concentrations in this patient were not due to any of the factors known to increase CBG. Consistently high basal serum GH levels and unusual GH responses to GH-releasing factor (GRF) and L -dopa were also noted.