Experimental Animals
Online ISSN : 1881-7122
Print ISSN : 1341-1357
ISSN-L : 0007-5124
Note
Underdevelopment of Fetal Thyroid Follicular Cells in Athymic Nude Mouse (BALB/cAnNCrj-nu/nu) Observed by Electron Microscopic Morphometry
Katsuyasu SAKITASatoko HOSHIHiroyoshi NINOMIYATomo INOMATA
著者情報
キーワード: fetus, nude mouse, thyroid gland
ジャーナル フリー

1999 年 48 巻 1 号 p. 47-50

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抄録

Fetal thyroid follicular cells of congenitally athymic nude mouse (BALB/cAnNCrj-nu/nu) were studied with an electron microscope. The area of the entire cell, nucleus and mitochondrion were measured and compared in athymic and euthymic fetal nude mice (BALB/cAnNCrj-nu/+) at 18 days of gestation. The mean area of cytoplasm was significantly smaller in homozygous athymic nude mice than in heterozygous euthymic ones. The mean area of the mitochondrion was also smaller in homozygous athymic nude mice, but the difference was not statistically significant. There was no significant difference between the two groups in the area of the nucleus. These findings suggest that the thyroid gland of athymic nude mice is still underdeveloped at the end of gestation as compared to that of their euthymic littermates.

著者関連情報
© 1999 Japanese Association for Laboratory Animal Science
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