Experimental Animals
Online ISSN : 1881-7122
Print ISSN : 1341-1357
ISSN-L : 0007-5124
Locus of Dominant Hairless Gene (Ht) Causing Abnormal Hair and Keratinization Maps to Rat Chromosome 10
Toshio AKIMOTOHiroetsu SUZUKIKazumasa NAKAMAKatsushi SUZUKI
キーワード: gene mapping, hairless, WBN/Ila-Ht rat
ジャーナル フリー

2000 年 49 巻 2 号 p. 137-140


The rat dominant hairless gene (Ht) of the WBN/Ila-Ht rat causes atrichosis in Ht/Ht and hypotrichosis in Ht/+. Furthermore the Ht/Ht shows signs of abnormal keratinization and almost all of the Ht/Ht die in an immature stage before weaning in the conventional environment. Ht/+ was affected by dermatitis caused by Staphylococcus aureus, suggesting that the gene Ht might involve defense mechanisms against infection. In this study, we performed the linkage analysis of the gene Ht by outocross with the Brown Norway rat in the SPF environment. Ninety-six backcross progeny of (BN × WBN/Ila-Ht/Ht) F1 × WBN/Ila-Ht/Ht were typed with microsatellite markers and the gene Ht was mapped on chromosome 10 between Asgr1 and Nos2 within the map distance of 6.2 cM.

© 2000 Japanese Association for Laboratory Animal Science
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