抄録
1,2,3,4,5,6-Cyclohexanehexol inositol consists of nine distinct stereoisomers. Myo-inositol (MI) is the most prominent isomer and is widely distributed in its free form or as a bound-component of inositol phosphates (eg, phytate) or phospholipids (eg, phosphatidylinositol) in plant and animal foods. MI prevents fatty liver, even when induced by a strong lipogenic sugar such as fructose, probably due to repression of fructolysis/glycolysis and fatty acid synthesis rather than enhancement of fatty acid β-oxidation. In addition, MI promotes glucose transporter 4 translocation due to potentiation of the insulin signaling pathway in skeletal muscle following secretion of insulin. This suggests that MI is useful for the prevention of metabolic diseases such as fatty liver and diabetes.
