Follicle cell被包卵母細胞 ATP/グリベンクラミド感受性カリウムチャネルの薬理

抄録

Follicle-enclosed Xenopus oocytes have endogenous glibenclamide-sensitive K⁺ channels that can be activated by K⁺ channel openers. Since the follicle-enclosed Xenopus oocytes can be easily voltage-clamped, the K⁺ channels are used as a model of the ATP/glibenclamide-sensitive K⁺ channels. So far, the effects of calmodulin antagonists, antiarrhythmics, anesthetics, antidepressants, histamine H₁-receptor antagonists, imidazolines and several hormones on the K⁺ channels of the oocytes have been reported. The pharmacological data on the K⁺ channels obtained from the oocyte-system may contribute to our understanding of the regulatory mechanism and physiological role of the ATP/glibenclamide-sensitive K⁺ channels.