Follicle-enclosed
Xenopus oocytes have endogenous glibenclamide-sensitive K
+ channels that can be activated by K
+ channel openers. Since the follicle-enclosed
Xenopus oocytes can be easily voltage-clamped, the K
+ channels are used as a model of the ATP/glibenclamide-sensitive K
+ channels. So far, the effects of calmodulin antagonists, antiarrhythmics, anesthetics, antidepressants, histamine H
1-receptor antagonists, imidazolines and several hormones on the K
+ channels of the oocytes have been reported. The pharmacological data on the K
+ channels obtained from the oocyte-system may contribute to our understanding of the regulatory mechanism and physiological role of the ATP/glibenclamide-sensitive K
+ channels.
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