Sulfathiazolの創傷面よりの吸收に關する實験的研究 第1報

抄録

Because of the insolubility of sulfathiazol, and thus poor absorption from wound surface little therapeutic effect is expected from external application. Therefore, in order to find the best method for external application of the drug the absorp tion of. the drug was tested by using different vehicles. Sulfathiazol (S) was mixed at a concentration of 10 % in 3 ointment bases, i.e. LV (lanolin 10+vaselin 90), HO (hydrophilic ointment) and PC (propylene glycol 50-carbowax (4000) 50).The S ointment were spread 2×2 cm squares of oil-paper and applied on the surface of wounds on the leg skin of a rabbit. Then the concentration of S in blood and urine was measured. with Tsuda's method at certain intervals of times. The results obtained were as follows : (1) When a small amount (0.1 g) of each ointment was applied, there were only slight differences between the three vehicles in the drug concentration in blood and in the quantity of the drug excreted in urine. (2) Although LV and HO increase the absorption and excretion of the drug in triple doses, doubling the dose did not influence the absorption and excretion. The ratio of the quantity excreted in urine to the dose (excretion ratio) was lower, the larger the dose. (3) When the dose of the PC-S ointment was tripled, the S concentration in blood was raised and the quantities excrted in urine and the duration of excretien were increased. The excretion ratio in this case was higher, the larger the dose.