日本薬理学雑誌
Online ISSN : 1347-8397
Print ISSN : 0015-5691
ISSN-L : 0015-5691
48 巻 , 4 号
選択された号の論文の16件中1~16を表示しています
  • 万波 忠三郎
    1952 年 48 巻 4 号 p. 159-171,en23
    発行日: 1952/10/20
    公開日: 2011/09/07
    ジャーナル フリー
    Several kinds of surface active agents-i.e., cationic : cetylmethyl diethyl ammonium methosulfate, cetylmethyl piperidinium methosulfate, non-ionic : Tween 20, Tween 60, and Span 20, anionic : dioctyl ester sodium sulfosuccinic acid, sodium oleate-were added according to the various steps of concentration to 0.01% solution of 4-n-cyclo-hexyl-6-chlororesorcinol (C. H. C. R.) in phosphate buffered, pH 7.5, frog-Ringers' solution. Then, the mortality percent of Spinicauda japonica Wilkie, a nematoda species inhabiting toad's large intestine, after immersed in these solutions for certain minutes, was observed by modified Lamson's method, and parallel measurement was carried out their interfacial tension against liquid-parrafin by Hillyer's drop method and du Nouy's ring method. The results obtained were : the soaps in dilute solution increased remarkably the biological activity of C. H. C. R. (as measured by the mortality percent) but when present in high 'concentration it decreased the activity. In these cases, the least concentration of soap to increase the biological activity of these solutions corresponded to the concentration at which the interfacial tenision bgins to fall, when measured by drop method, but not by ring method, but the maximum acceleration ot the activity occurred at the concentration where the interfacial tension by ring method indicated minimum. However, in the case of Tween, such acceleration of the biological activity of the solution was not observed throughout its concentrations, and the more concentrated the more markedly decreased. These results were discussed from the sufacechemical point of view.
  • 万波 忠三郎
    1952 年 48 巻 4 号 p. 172-184,en23
    発行日: 1952/10/20
    公開日: 2011/09/07
    ジャーナル フリー
    On the combinations between 4-cyclohexyl-6-chlororesorcinol. (C. H. C. R.) and 4-n-octyl-6-chlororesorcinol (O. C. R.), C. H. C. R. and 4-n-octylresorcinol (O. R.), remarkable potentiation of the efficiency in combating ascaris was observed in certain ratio of mixture. The most efficient ratio of mixture, in both cases lay within the rang e of from 90% of C. H. C. R. contained. Oral toxicity tomice, local irritant action (examined on conjunctiva of rabbits, human tongues and gastric mucosa of dogs and also clinical side effects of these mixtures of most efficatious ratios did not significantly differ from those of C. H. C. R., the fact revealing no potentiation in such aspects. These mixtures proved, to be superior in anthelmintic efficacy and less toxic and less irritant than hexylresorcinol. Some physical changes such as a fall of melting, point and a lowering of interfacial tension of solution are supposed to be important factors in the mechanism of anthelmintic potentiation of these mixtures.
  • 君塚 通雄
    1952 年 48 巻 4 号 p. 185-208,en24
    発行日: 1952/10/20
    公開日: 2011/09/07
    ジャーナル フリー
    Experiments were performed under the normal physiological conditions on a caged rat with free access to water. The diuretic action and the amount of water drunk were compared at regular. intervals after the oral administration of diuretics of various kinds, such as coffein, theocin, urea, potassium chloride, potassium and sodium salts of acetic, succinic and suberic acid. All the experiments were planned statistically and carried out with the method, of uniformity test, and of cross test as, well : as with. Latin square method. First, in the method of uniformity test, 10 mg, 30 mg and 60, mg of. caffein, and, theocin were respectively administered per kg body. weight.but neither diuretic action nor an increase in the amount of water drunk were recognized. Then, 1, 000 mg of urea and 300 mg per kg of potassium chloride were administered. In the case of urea, a remarkable diuretic effect and an increase in the amount of water drunk were recognized. In the case of potassium chloride, temporary diuretic effect was found immediately after its administration and then, the amount of urine gradually decreased and in 5 or 6 days became smaller than before the administration. In the case where 23.5 mg of potassium acetate, 23 mg of potassium succinate and 30 mg of potassium suberate kneaded with a constant amount of wheat flour respectively (each dose is equimolar to the other) were administered, neither diuretic effect nor increase in amount of water drunk was observed, whereas with doses ten times as much as the doses of these compounds respectively, all caused distinct diuretic and increase in the amount of water drunk, although the effect of potassium succinate is less remarkable than those of the other two. Next, the experiments were made by the method of cross test. In this case, too, almost the same distinct diuretic effect and increase in the am ount of water were observed, by using potassium. acetate and potassium usberate. Furthermore, the results obtained by the Latin-square method with those compounds were the same as those of the above-mentioned two methods. When experiments were carried, out in the same, manner as before with their sodium salts instead of potassium salts, suberate showed a slight diuretic effect, while no diuretic action was. recognized in the cases of both acetate and succinate.
  • 村野 匡
    1952 年 48 巻 4 号 p. 209-226,en24
    発行日: 1952/10/20
    公開日: 2011/09/07
    ジャーナル フリー
    The chronic actions of antihistaminics were studied on the mice, injected daily with Restamin (β-dimethylamino-ethylbenzohydryl-ether-HCl) or Anergen (N-dimethylaminoethylphenothiazine-HCl) for 80-120 days, and the combined actions of antihistaminics and central paralytics or stimulants were observed. The results obtained were as follows : (1) Restamin was found to have excitative and paralytic action on the mice, while Anergen showed only a paralytic action. The acute toxicity of Restamin was stronger on the mice than that of Anergen, but by the chronic toxicity it was reversed. Antagonism of histamine to antihistaminics was observed obscurely on the mice treated with Restamin. (2) The combination of Restamin and the central paralytics increased the sedative action and decreased the Restamin toxicity, while the combination of Restamin and the central stimulants increased the stimulant action. resulting convulsions and the Restamin toxicity. On the contrary, the combination of Anergen and the central paralytics exerted no obvious potentiation in their sedative actions; Anergen was, however, observed antagonistic to the convulsions due to the central stimulants. (3) Antagonism between histamine and Restamin was observed on the isolated intestine of mice treated with Restamin, but not proved, on mice with Anergen. (4) By the experiments. on the tissue respiration the. liver, intestine and. brain of mice injected with Restamin for a short time, became hypersensitive to Restamin, after repeated 80-130 times of injections of Restamin, however, these tissues became hyposensitive. On the contrary, the tissues of the Anergen mice maintained continuously the hypersensitiveness to Anergen. (5) The distribution pattern of Restamin in the bodies of the Restamin mice was observed to be differed from controls.
  • 村野 匡
    1952 年 48 巻 4 号 p. 227-230,en25
    発行日: 1952/10/20
    公開日: 2011/09/07
    ジャーナル フリー
    Histamineの各種動物剔出子宮運動に對する作用に關しては, Abel3), Macht3), Laidlaw4), Guggenheim2) 及び本邦では杉本5), 西山等の詳細な實驗報告がある.即ち氏等は動物の種類及び同種の動物に於ても個性によりその感受性に著しい差異があり, 多くの動物の剔出子宮はHistamineにより, 緊張の上昇, 振幅の増大, 自發運動の増加を來すが, 獨り白鼠剔出子宮のみは極めて少数の例外を除き常に緊張の低下を來すと述べている.又最近臨床上廣く應用されている抗Histamine劑は化學構造上Histamineと多少相似した型を持ち.摘出子宮に對しては緊張上昇的に作用し, 併もHistamine收縮作用に拮抗するといわれている.然し乍ら種々な動物子宮に於て此の點を比較觀察した報告はなく殊に性週期又は卵巣ホルモンが之等の作用に如何なる影響を及ぼすかに關しては殆ど報告されていない.
    茲に於て私は家兎, 海〓, 及び白鼠を使用して抗Histamine劑の之等動物剔出子宮に對する作用の比較檢討を試み同時に性週期並に卵巣ホルモンの該劑作用に及ぼす影響更にHistamineとの相互關係を檢索した.
  • 白髭 壽男
    1952 年 48 巻 4 号 p. 231-237,en26
    発行日: 1952/10/20
    公開日: 2011/09/07
    ジャーナル フリー
    Because of the insolubility of sulfathiazol, and thus poor absorption from wound surface little therapeutic effect is expected from external application. Therefore, in order to find the best method for external application of the drug the absorp tion of. the drug was tested by using different vehicles. Sulfathiazol (S) was mixed at a concentration of 10 % in 3 ointment bases, i.e. LV (lanolin 10+vaselin 90), HO (hydrophilic ointment) and PC (propylene glycol 50-carbowax (4000) 50).The S ointment were spread 2×2 cm squares of oil-paper and applied on the surface of wounds on the leg skin of a rabbit. Then the concentration of S in blood and urine was measured. with Tsuda's method at certain intervals of times. The results obtained were as follows : (1) When a small amount (0.1 g) of each ointment was applied, there were only slight differences between the three vehicles in the drug concentration in blood and in the quantity of the drug excreted in urine. (2) Although LV and HO increase the absorption and excretion of the drug in triple doses, doubling the dose did not influence the absorption and excretion. The ratio of the quantity excreted in urine to the dose (excretion ratio) was lower, the larger the dose. (3) When the dose of the PC-S ointment was tripled, the S concentration in blood was raised and the quantities excrted in urine and the duration of excretien were increased. The excretion ratio in this case was higher, the larger the dose.
  • 藤下 春敏
    1952 年 48 巻 4 号 p. 238-243,en26
    発行日: 1952/10/20
    公開日: 2011/09/07
    ジャーナル フリー
    Quantitative estimations of free santonin were determined in-the urine and intestinal tract of a rabbit following oral, subcutaneous and intravenous administration. The analytic method for this purpose was previously reported in detail (Nagasaki Igakkai Zassi in press).. The results obtained were as follows : (1) The ratio of the quantity of santonin excreted in the urine to the dose amounted to 6.7 27.7 % after oral administration ; to 64.9 77.4%; after subcutaneous administration of sodium santonin ; to 673-82.8 % after intravenous administration of the salt. Since individual variations in the excretion of santonin are great, the same rabbit was used to avoid experimental error. (2) Most of the santonin was excreted within the first 9 hrs. after oral administration, and in the first 3 hrs. after injection of sodiums santoninate. (3) Whenever oral administration of santonin was repeated in a rabbit excreting a large quantity of the drug at the first administration, the amount excreted in the urine, fell to a constant value after several administrations. (4) No santonin could be detected in the feces, but a qualitative test for santonin was positive in the bile and intestinal tract. (5), Seven rug of santonin (1%) was found in the bile of a rabbit whose liver and kidneys were injured by repeated large doses of santonin.
  • 藤下 春敏
    1952 年 48 巻 4 号 p. 244-247,en27
    発行日: 1952/10/20
    公開日: 2011/09/07
    ジャーナル フリー
    The influence of liver function on the urinary excretion of unchanged santonin was investigated in rabbits. The results obtained were as follows. After the liver was damaged by CCl4 the urinary excretion of santonin increased markedly over the control ; it was decreased when the function of liver was stimulated by dehydrocholic acid or sodium thiosulphate. These results showed conversely the same relation that oxysantonin was excret. ed in the urine proportionally to the function of liver, and it was accordingly considered that santonin would be changed to oxysantonin in liver.
  • 藤竹 信英
    1952 年 48 巻 4 号 p. 248-251,en27
    発行日: 1952/10/20
    公開日: 2011/09/07
    ジャーナル フリー
    The anticonvulsive activities of such drugs as o-tolylglycerylether (Myanesin), guaiacol glycerylether, isotetradrin ammonium hydroxide, isotetrandrin ammonium chloride, isotrilobin and d-tubocurarine were comparatively examined by the head-drop dose of rabbits and mice and discussed on the superiority of the former method with rabbits to the latter.
  • 小川 和榮
    1952 年 48 巻 4 号 p. 252-258,en27
    発行日: 1952/10/20
    公開日: 2011/09/07
    ジャーナル フリー
    視丘が催眠およびその持續に軍要な關係があることは, 古くより考えられていることでTrõmner, Ecomonoも申腦から間腦への移行部に眠りの調節申樞があるとし, Hessは猫の視丘下部を電氣刺戟して眠りの成立を賓驗している.しかしHorrisonはこの部の剖見で傷害がないときはむしろ興奮が來ることを證している.Demoaeの實驗でも, この部位へCaCl2を注入、するときは催眠作用があるが, KClでは興奮が來, 眠りが生じて來なかつたという.またBerggrenらはKClでも催眠あり, 視丘下部の漏斗部に中樞があるとしている.一方Marainescoらは第三脳室壁を陽極刺戟し, または機械的に傷害して催眠を證明している.
    これらの研究から推して, 精確な位置を想定するに困難であるが, 中腦間腦菱腦が, 特にまた視丘下部が眠りに對して重要な機關であることに意見が一致していて, 更に覺醒と催眠との拮抗的機能がこの部にあるらしいことが想像できる.
    Pickらの研究で, 催眠藥の一部は主に親床下部に作用し眠りをおこすことが證されている.この際體位反射が浩えることが自然の眠りと相違しているが, 視床下部以外の脳部分にも麻痺的に作用するために, 反射消失を考えることができるにしても, 藥物催眠では自然の眠りほど突然覺醒させることが難しいから, 兩者が本態的に異ることは確かであろう.つまり義應自然催眠をおこす部位を催眠藥作用部位と別に想際することができよう.後者の麻痺と同様な前者の興奮による抑制的機序があり得ると考えられる.中樞興奮作用的藥物のカフエイン, コカイン, によつて時に人に眠りがおきることが知られているが, カンフアーの興奮的作用によつても催眠が見られることが臨床醫家がら屡々報告されている.これには心臓機能の恢復, 血液循環の促進のための身體的精神的快感が眠りを與えることも考えられるが, 實驗的にこの事實を檢計するために以下の實驗を行つた.
  • 山本 政市, 古川 聰, 松田 勝一
    1952 年 48 巻 4 号 p. 259-264,en27
    発行日: 1952/10/20
    公開日: 2011/09/07
    ジャーナル フリー
    第6局方所載ジギタリス効力試驗方法を要約すれば, “健全な體重15-309のトノサマガエノしの3匹宛を1群として, 約4%のジギタリス浸液をその兩大腿リンパ嚢内に, 全量なるべく0.2cc以下なるようにして等容量を注射する.環界温度15-25℃で4h後における致死の割合をしらべる.各群注射用量の差は, 第1回20%, 更に精査のため第2回10%とする.定められた標準品に對して検體1g中の單位数を10× (標準品最小致死量/検體最小致死量) によつて單位を算出する.但し最小致死量とは3匹中2匹が死亡する最小量をいう” にある.
    この方法はドイツ局方の検定方法に從つたものと思われるが, 同方法では25-40gの體重のRana temporariaを用い, 4%浸液を10%の用量差で全容量0.5ccを越えぬようにして皮下注射し, 4h後の結果をKarber法で計算してLD 50を求めることになつている.各群蛙数は5匹である.7, 8, 9月は検査を行わない.標準品1gは蛙體重2000gを死亡せしめる.
    これに關して, われわれはまず一般的な問題がらほじめて具體的の試験まで論じてゆきたいと思う.
  • 三上 憲一
    1952 年 48 巻 4 号 p. 265-272,en28
    発行日: 1952/10/20
    公開日: 2011/09/07
    ジャーナル フリー
    Analyzing the fators of “Cocaineinactivation” by rabbit's liver the following results were obtained. (1) By the biological estimation of cocaine it was demonstrated that the liver extract of rabbits could inactivate cocaine and its important mechanism was suggested to be destruction. (2) Its destructive products, methyl alcohol, bezoic acid and ecgonine, were chemically demonstrated. (3) The quantitative micro-determination of benzoic acid was testified to be albe to measure benzoic acid derived from cocaine by rabbitt's liver extract. (4) Using this method, it could be proved that the production of benzoic acid was enzymatically performed. (5) The destructive ability was compared among the tissues of rabbits and the livers of several animals, and the liver of rabbits showed the most active destruction.
  • 1952 年 48 巻 4 号 p. e1a
    発行日: 1952年
    公開日: 2011/09/07
    ジャーナル フリー
  • 1952 年 48 巻 4 号 p. e1b
    発行日: 1952年
    公開日: 2011/09/07
    ジャーナル フリー
  • 1952 年 48 巻 4 号 p. e1c
    発行日: 1952年
    公開日: 2011/09/07
    ジャーナル フリー
  • 1952 年 48 巻 4 号 p. e1d
    発行日: 1952年
    公開日: 2011/09/07
    ジャーナル フリー
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