諸種薬物の摘出子宮蓮動曲線に関する研究 特に子宮縦走筋及び環状筋に対する作用態度より見たる曲線の吟味

抄録

The motilities of the isolated uterine strip, and longitudinal or circular muscle from the uterus of the rabbit, the guinea-pig and the rat were recorded, and the internal pressure of uterus was measured simultaneously. The behaviors on these strips have been examined for the following drugs: adrenaline, ephedrine, tyramine, acetylcholine, histamine, papaverine and magnesium chloride. Adrenaline, ephedrine, tyramine, acetylcholine and histamine caused the contraction of the isolated uterine strip of the rabbit, while sometimes caused the relaxation. But these drugs caused the contraction of longitudinal and circular muscle isolated from the uterus. Therefore, it seemed that the relaxation of the whole uterine strip caused by these drugs was due to more predominant contraction of the circular muscle than that of the longitudinal muscle. This curious phenomenon was not observed on the isolated uterine strips of the guinea-pig or the rat. Papaverine and magnesium chloride caused the relaxation of both the circular and longitudinal muscle. Above mentioned action of these drugs was observed on the isolated strip of the pregnant or non pregnant, and the confined or not confined rabbits. Dibenamine inhibited the relaxation of the isolated strip of the rabbit uterus caused by sympathetic amines, while did not inhibit the relaxation of that of the guinea-pig or the rat caused by these amines.