抄録
The urinary excretion of free santonin in rabbits was observed after administering santonin by 3 different methods: Subcutaneous injection of 10% solution of sodium santoninate, oral administration of santonin, and intramuscular injection of 2 % and 3 io santonin-propyleneglycol (PG). The dosages were all equivalent to 100 mg of santonin. The results obtained were as follows : The urinary excretion of santonin began at 5-15 min. after injection of sodium santoninate, at 10-15 min. after oral administration of santonin and at 15-50 min. after intramuscular injection of santonin-PG. The excretion of santonin continued for 16 hrs. after the injection of sodium santoninate, for 21 hrs. after the oral administration of santonin and for 24 and 59 hrs. respectively after the injection of 2% and 3% santonin-PG. Santonin recovered in urine amounted to 57.4% of the injection of sodium santoninate, to 19.9% of the orally administered santonin, and to 15.8% and 6.4% respectively of the injection of 2% and 3% santonin-PG.
