結晶性規那アルカロイドの局所 麻醉作用の比較觀察

抄録

The local anesthetic efficacy of the crystalline alkaloids, quinine, quinidine and cinchonine, was studied, using corneae of rabbits and sciatie nerves of frogs for the tests, in mutual comparison and in comparison with cocaine and percaine. The results were summarized as in the following : 1) All the three cinchona alkaloids showed efficacy in local anesthetizing, but they were weaker, than cocaine in this respect. 2) Among the three, quinidine showed the strongest and cinchonine the weakest efficacy on the corneae of rabbits, quinine coming between the two, while in the tests with the frog's sciatic nerve, quinine and quinidine were almost equally efficacious, cinchonine being only slightly anesthetic.