2-Methylaminomethyl 2, 3-dihydrobenzofuran (EPS-4032)の鎮痛作用
マウスにおける作用パタン
1971 年 67 巻 5-6 号 p. 580-594
詳細
1971 年 67 巻 5-6 号 p. 580-594
2-Methylaminomethyl 2, 3-dihydrobenzofuran (EPS-4032) revealed relatively potent analgesic effect on various method in mice. Its effect was roughly equivalent to codein and as 5 times potent as aminopyrine. Morphine analgesia was apparently antagonized by levallorphan, while EPS-4032 analgesia was markedly potentiated by it, as well as aminopyrine. In the animals pretreated with reserpine or tetrabenazine, EPS-4032 and morphine failed to produced analgesic action. However, this antagonism was disappeared by administration of 1-DOPA after tetrabenazine. Analgesic effect of EPS-4030 was significantly intencified with pretreatment of nialamide and SKF-525A, but apparently reduced by pretreatment of phenobarbital. Also slight developement of tolerance was observed by repeated administration of EPS-4032 on mice.
