モルモット輸精管に対するcatecholamineと強心配糖体の相互作用について

抄録

The present study was undertaken in order to elucidate the site of drug interaction between digitalis and catecholamines. Experiments were designed to test the effect of digitalis glycoside on catecholamine-induced contraction of vas deferens isolated from guinea pig. Ouabain potentiated the catecholamine-induced contraction of vas deferens. Potentiation by interaction between ouabain and catecholamine was not produced following administration of phenoxybenzamine. In a potassium free medium, ouabain did not produce potentiation of the catecholamine-induced contraction. These results suggest that the interrelated potentiation between catecholamines and ouabain is at the site of the α-adrenergic recepter.