抄録
Here is presented a case of erosive gastritis with marked hypoproteinemia, with special consideration on the effect of antiplasmin treatment for about 7 months. A 26-year-old male was admitted to our institute on 10 th Feb., 1975, with chief complaint of diarrhea, which continued preceeding several days. Physical examination was nothing contributory, but radiological and endoscopic examination of the stomach revealed numerous gastric erosions in different size and stages. On biochemical examination, the most remarkable finding was hypoproteinemia, as low as 4.5g/dl. But there was not anemia nor electrolyte imbalance. 131I-PVP test revealed recovery of 3.7% of injected material, which confirmed the proteinlosing process in the G-I tract. Gastric juice analysis showed unusual high level of protein content. The measurement of f ibrinolytic activity of the gastric mucosa was carried out according to the method of Astrup(The value of this examination was firstly reported by Kondo et al. in 1974.). The f ibrinolytic activity was high in this patient. While, the results of radiological and functional examination of the small intestine was not suggestive of the enteropathy. All of these results indicated at least the diagnosis of protein-losing gastropathy. As the treatment, t-AMCHA 3g daily was given to this patient as was recommended by Kondo et al., but even after 7 months with this treatment, serum protein did not return to normal level. All through the period, serum protein showed fluctuation from 4.5 to 5.5g/dl, without any significant correlation to wax and wane of the erosive gastritis.
