抄録
Hyperuricemia is sometimes associated with various blood dyscrasias including leukemia and lymphoma, while it is rarely found in patients with nonlymphomatous solid tumors.
We reported two cases of hyperuricemic renal failure caused by solid malignant tumors. Case 1 was 51-year-old male of esophagus cancer. Laboratory data on admission were as follows: BUN,69.4 mg/dl; serum creatinine,3.8 mg/dl; uric acid,26.5 mg/dl; and LDH,1960 IU. He was treated with peritoneal dialysis. Case 2 was 60-year-old female of gastric cancer, who showed the following laboratory data: BUN,78.1 mg/dl; serum creatinine,3.1 mg/dl; uric acid,26.2 mg/dl; and LDH,624 IU.
Statistical analysis was performed on 100 patients with nonlymphomatous solid tumor. Hyperuricemia was found in 6 % of them. Hyperuricemic patients were demonstrated to have elevated blood urea nitrogen and creatinine. Furthermore, they had raised levels of GOT, LDH, total bilirubin and alkaline phosphatase, being signicantly higher (p<0.001)than normouricemics. All of six hyperuricemic patients had massive liver metastasis.
Hyperuricemia associated with solid tumor could be related to the presence of widespread massive metastasis, especially the involevement of liver.
