抄録
This study was performed to examine whether exerciseinduced hyperurico-phenomenon depended on increased production of uric acid or decreased renal excretion of uric acid.
Exhaustive exercise on treadmill was performed i n 5 healthy subjects, mean age 22 years (20-24). In allopurinol exper iment, the subjects were administered 200 mg of allopurinol after breakfast 2 hours prior to exercise. In benecid experiment,1000 mg of benecid was administered. No drug was administered in control experiment.
In three experiments, we had no differencein VO2max, HRmax, running time, blood lactate and serum CPK. There was no significant difference in urinary excretion of 3-methylhistidine. The elevation of serum uric acid was the highest in control experiment (+1.56 mg/dl at 1 hour after exercise), which did not return to the initial level even 7 hours after exercise. The serum uric acid concentration of benecid experiment increased as much as control experiment 1 hour after exercise (+1.23 mg/d1), decreased after that and remained below the initial level since 3 hours after exercise. However, no increase of serum uric acid was observed in allopurinol experiment, which remained till 7 hours after exercise. On the other hand, urinary excretion of uric acid, uric acid clearance, creatinine clearance and clearance ratio were maintained higher level in benecid experiment than in other experiments.
These observations suggest that increased production of uric acid had more influence on the appearance of exerciseinduced hyperurico-phenomenon than decreased renal excretion of uric acid.
