抄録
Norepinephrine (NE) has a great important role in antiepileptic effects in vagus nerve stimulation and neuromodulation. There exists knowledge about NE effects on organ and neuron, however little is known about ones on neuronal network. Here we evaluated the NE effects on cultured neuronal network on microelectrode array (MEA) with analysis based on spikes, electrode bursts which are bursts recorded in a single electrode, network bursts, and Fourier spectrum. Multiple NE administrations show significant decrease in number of spikes, electrode bursts, and network bursts and other indices of those activities. Furthermore, average spike rate and normalized Fourier spectrum show that the administrations decrease the baseline of activity and emphasize periodic activity. These results suggest that NE has antiepileptic effects by decreasing synchronized activity and neuromodulation by emphasis on periodic activity.
