Design and Fabrication of Biosensor Device by Use of Receptor Proteins

抄録

We have been studying a new type of biosensor that uses and mimics sensory functions of insects. The biosensor can be characterized in combination with immobilized signal transduction biomolecules, i.e., receptor proteins, and a semiconductor device as a transducer. We have developed a lipid bilayer membrane for receptor immobilization and combined it with an insulated-gate field-effect transistor (IGFET). By using this bilayer-IGFET device, we have measured changes in the bilayer membrane potential after introducing α-hemolysin, which acts as a model of receptors. This indicates that the developed device could be used for the biosensor using receptor proteins.