電気学会論文誌E(センサ・マイクロマシン部門誌)
Online ISSN : 1347-5525
Print ISSN : 1341-8939
ISSN-L : 1341-8939
特集解説
電位計測型Solid-state biosensorの界面制御と分子認識検出
宮原 裕二田畑 美幸
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2022 年 142 巻 5 号 p. 72-77

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We have been investigating functions of interfaces between different materials in potentiometric solid-state biosensors for stabilization of the electromotive forces (EMFs). The solid-state ion sensor showed a stable EMF only when the intermediate layer contained the primary ions and chloride ions. This indicated that an efficient ion exchange process was necessary at all interfaces involved, including a thin water layer, for a stable EMF of the solid-state ion sensor. A solid-state biosensor based on the organic and inorganic mixed phase modification of a silver surface was proposed as the second example. Stabilization of the EMF and functionalization with biomolecules on the sensing surface were simultaneously achieved using silver chloride and a self-assembled monolayer with oligonucleotide probes. The proposed schemes could be useful as stable solid-contacts for potentiometric sensor in biomedical fields such as liquid biopsy platforms and wearable sensors.

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