DAMAGING EFFECT OF CADMIUM OXIDE DUST TO THE LUNG AND ITS RELATION TO SOLUBILITY OF THE DUST
1978 年 16 巻 2 号 p. 81-89
詳細
1978 年 16 巻 2 号 p. 81-89
The effects of cadmium oxide dusts on the rat lung were studied after exposure of 90min with its concentration of 19.5mg/m3, and for the comparison the similar experiments were carried out on calcium carbonate and polyvinyl chloride dusts with different concentrations.
Alveolar macrophages, protein and phospholipid in the lung washing fluids of rats as well as the lung weights were determined 1 hr and 21 hr after exposure to each dust.
Remarkable points in the results were the decrease in number of macrophages and increase of protein 21 hr after exposure to cadmium oxide dusts. The decrease of macrophages was observed also 1 hr after exposure to cadmium oxide dusts. Cadmium oxide dusts were dissolved easily in water or Tyrode's solution added with protein or amino acid as in the case of cadmium fume reported previously.
Cadmium oxide dusts added in the washing fluid from the lung of rats 21 hr after exposure showed a higher solubility compared with that added in the washing fluid from non-exposed (control) rat lung.
Cadmium which was dissolved from cadmium oxide dusts in albumin or glycine solution showed a strong toxic action on the intraperitoneal macrophages and 3T6 cells.
From these results, decrease of macrophages and increase of protein in the lung washing fluid by exposure to cadmium oxide dusts was assumed to be evoked by the toxic action of cadmium of which solubility was enhanced by the biological medium in the lung containing protein and others.
