Marked Improvement with Sildenafil in a Patient with Idiopathic Pulmonary Arterial Hypertension Unresponsive to Beraprost and Sarpogrelate

Hiroaki Kawano; Hideyori Sengyoku; Osami Satoh; Shigetoshi Urabe; Yuji Koide; Katsusuke Yano

doi:10.2169/internalmedicine.46.1848

CASE REPORTS

Marked Improvement with Sildenafil in a Patient with Idiopathic Pulmonary Arterial Hypertension Unresponsive to Beraprost and Sarpogrelate

Hiroaki Kawano, Hideyori Sengyoku, Osami Satoh, Shigetoshi Urabe, Yuji Koide, Katsusuke Yano

著者情報

キーワード: beraprost, saprogrelate, sildenafil, pulmonary hypertension, treatment

ジャーナルオープンアクセス

2007 年 46 巻 12 号 p. 893-898

DOI https://doi.org/10.2169/internalmedicine.46.1848

詳細

抄録

We report a 16-year-old man with severe heart failure due to idiopathic pulmonary arterial hypertension (IPAH). The patient was initially treated with a combination of beraprost, a prostacyclin analog, and sarpogrelate, a serotonin receptor inhibitor. However, he was unresponsive to the treatment. We then changed the treatment to sildenafil, and his condition dramatically improved. Sildenafil has an immediate pulmonary vasodilator effect in patients already receiving vasodilators for IPAH.

責任著者(Corresponding author)

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