Remitting Seronegative Symmetrical Synovitis with Pitting Edema (RS₃PE) Syndrome Accompanied by Parkinson's Disease

抄録

We encountered two cases of RS₃PE (remitting seronegative symmetrical synovitis with pitting edema) syndrome accompanied by Parkinson's disease (PD). Although the etiology of RS₃PE syndrome is still unknown, several possible associations, such as malignancies and viral infections, have been reported; RS₃PE syndrome is thought to be an autoimmune-mediated disorder. The present patients did not have any factors which are reported to be associated with RS₃PE. Whether or not the complication of PD and RS₃PE syndrome is incidental needs to be further examined, and we discuss here the possible cause of association between PD and RS₃PE syndrome, including dopamine agonists one of the anti-PD medications.