Mantle Cell Lymphoma Mainly Involving Thoracic Lesions: Two Case Reports

Makoto Kosaka; Tomonobu Koizumi; Toshirou Fukushima; Yousuke Wada; Toshihiko Agatsuma; Toshiki Yokoyama; Shintorou Kanda; Keishi Kubo; Hisashi Shimojo; Shirou Horie; Naoko Asano

doi:10.2169/internalmedicine.50.5335

CASE REPORTS

Mantle Cell Lymphoma Mainly Involving Thoracic Lesions: Two Case Reports

Makoto Kosaka, Tomonobu Koizumi, Toshirou Fukushima, Yousuke Wada, Toshihiko Agatsuma, Toshiki Yokoyama, Shintorou Kanda, Keishi Kubo, Hisashi Shimojo, Shirou Horie, Naoko Asano

著者情報

キーワード: hilar lymphadenopathy, R-CHOP, chemotherapy, non-Hodgkin lymphoma

ジャーナルオープンアクセス

2011 年 50 巻 14 号 p. 1477-1481

DOI https://doi.org/10.2169/internalmedicine.50.5335

詳細

抄録

Most mantle cell lymphoma patients show remarkable disseminated disease at the initial diagnosis. We describe two cases of mantle cell lymphoma mainly involving thoracic lesions at the initial presentation of the disease. The clinical presentations were right hilar lymphadenopathy in one case and right pleural thickness in the other. The diagnosis of mantle cell lymphoma was confirmed by immunohistochemistry, including CD5, CD20, and cyclin D1, and the presence of t(11 ; 14)(q13 ; q32) by fluorescence in situ hybridization. These thoracic manifestations at the initial diagnosis should be taken into consideration for the clinical spectrum of mantle cell lymphoma.

責任著者(Corresponding author)

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