Prominent Hypereosinophilia with Disseminated Intravascular Coagulation as an Unusual Presentation of Advanced Gastric Cancer

Haruhiko Takeda; Hiroki Nishikawa; Takehiko Tsumura; Akira Sekikawa; Takanori Maruo; Yoshihiro Okabe; Toru Kimura; Tomoko Wakasa; Yukio Osaki

doi:10.2169/internalmedicine.53.1483

CASE REPORTS

Prominent Hypereosinophilia with Disseminated Intravascular Coagulation as an Unusual Presentation of Advanced Gastric Cancer

Haruhiko Takeda, Hiroki Nishikawa, Takehiko Tsumura, Akira Sekikawa, Takanori Maruo, Yoshihiro Okabe, Toru Kimura, Tomoko Wakasa, Yukio Osaki

著者情報

Haruhiko Takeda
Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, Japan
Hiroki Nishikawa
Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, Japan
Takehiko Tsumura
Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, Japan
Akira Sekikawa
Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, Japan
Takanori Maruo
Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, Japan
Yoshihiro Okabe
Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, Japan
Toru Kimura
Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, Japan
Tomoko Wakasa
Department of Pathology, Osaka Red Cross Hospital, Japan
Yukio Osaki
Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, Japan

キーワード: advanced gastric cancer, cisplatin, disseminated bone marrow carcinomatosis, disseminated intravascular coagulation, eosinophilia, S-1

ジャーナルオープンアクセス

2014 年 53 巻 6 号 p. 563-569

DOI https://doi.org/10.2169/internalmedicine.53.1483

詳細

抄録

A 78-year-old woman was admitted to our hospital complaining of anorexia and purpura of the extremities. She presented with prominent peripheral eosinophilia and disseminated intravascular coagulation (DIC). Despite receiving intensive therapy for DIC, her illness worsened. Esophagogastroduodenoscopy revealed advanced gastric cancer (AGC), and a bone marrow biopsy led to a diagnosis of disseminated carcinomatosis of the bone marrow caused by AGC. We initiated combination chemotherapy with S-1 and cisplatin, which lead to a significant improvement of the DIC and eosinophilia, and the patient was finally discharged. The primary symptoms of DIC and eosinophilia were both considered to be caused by AGC, and we successfully treated the patient's critical condition.

責任著者(Corresponding author)

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