Six Cases of Pulmonary Mycobacterium shinjukuense Infection at a Single Hospital

Keita Takeda; Nobuharu Ohshima; Hideaki Nagai; Ryota Sato; Takahiro Ando; Kei Kusaka; Masahiro Kawashima; Kimihiko Masuda; Hirotoshi Matsui; Akio Aono; Kinuyo Chikamatsu; Satoshi Mitarai; Ken Ohta

doi:10.2169/internalmedicine.55.5460

CASE REPORTS

Six Cases of Pulmonary Mycobacterium shinjukuense Infection at a Single Hospital

Keita Takeda, Nobuharu Ohshima, Hideaki Nagai, Ryota Sato, Takahiro Ando, Kei Kusaka, Masahiro Kawashima, Kimihiko Masuda, Hirotoshi Matsui, Akio Aono, Kinuyo Chikamatsu, Satoshi Mitarai, Ken Ohta

著者情報

Keita Takeda
Center for Pulmonary Diseases, National Hospital Organization Tokyo National Hospital, Japan
Nobuharu Ohshima
Asthma and Allergy Center, National Hospital Organization Tokyo National Hospital, Japan
Hideaki Nagai
Center for Pulmonary Diseases, National Hospital Organization Tokyo National Hospital, Japan
Ryota Sato
Center for Pulmonary Diseases, National Hospital Organization Tokyo National Hospital, Japan
Takahiro Ando
Center for Pulmonary Diseases, National Hospital Organization Tokyo National Hospital, Japan
Kei Kusaka
Center for Pulmonary Diseases, National Hospital Organization Tokyo National Hospital, Japan
Masahiro Kawashima
Center for Pulmonary Diseases, National Hospital Organization Tokyo National Hospital, Japan
Kimihiko Masuda
Center for Pulmonary Diseases, National Hospital Organization Tokyo National Hospital, Japan
Hirotoshi Matsui
Center for Pulmonary Diseases, National Hospital Organization Tokyo National Hospital, Japan
Akio Aono
The Reference Centre for Mycobacterium, The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Japan
Kinuyo Chikamatsu
The Reference Centre for Mycobacterium, The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Japan
Satoshi Mitarai
The Reference Centre for Mycobacterium, The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Japan
Ken Ohta
Asthma and Allergy Center, National Hospital Organization Tokyo National Hospital, Japan

キーワード: Mycobacterium shinjukuense, nontuberculous mycobacteriosis, CT imaging, chemotherapy

ジャーナルオープンアクセス

2016 年 55 巻 7 号 p. 787-791

DOI https://doi.org/10.2169/internalmedicine.55.5460

詳細

抄録

Mycobacterium shinjukuense lung disease was diagnosed in 3 men and 3 women [mean age: 77.0±12.2 (57-93) years]. On imaging, 3 patients with previous pulmonary tuberculosis exhibited a fibrocavitary pattern, while the other 3 patients showed nodular bronchiectasis. A test with a tuberculosis rRNA identification kit (TRC Rapid^® M. TB) was falsely positive for M. tuberculosis due to DNA sequence similarity in 16SrRNA. M. shinjukuense was identified by the gene sequences of rpoB, 16S rRNA, and hsp65. The symptoms and imaging findings of most of the patients have improved with chemotherapy with low minimum inhibitory concentrations of anti-tuberculosis drugs.

責任著者(Corresponding author)

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