Anti-signal Recognition Particle Antibody-positive Necrotizing Myopathy with Secondary Cardiomyopathy: The First Myocardial Biopsy- and Multimodal Imaging-proven Case

Shiori Takeguchi-Kikuchi; Taiki Hayasaka; Takayuki Katayama; Kohei Kano; Kae Takahashi; Tsukasa Saito; Jun Sawada; Akiho Minoshima; Naka Sakamoto; Kazumi Akasaka; Naoyuki Miyokawa; Ichizo Nishino; Hatsue Ishibashi-Ueda; Naoyuki Hasebe

doi:10.2169/internalmedicine.2564-18

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引用する場合も本公開記事を引用してください。

Anti-signal Recognition Particle Antibody-positive Necrotizing Myopathy with Secondary Cardiomyopathy: The First Myocardial Biopsy- and Multimodal Imaging-proven Case

Shiori Takeguchi-Kikuchi, Taiki Hayasaka, Takayuki Katayama, Kohei Kano, Kae Takahashi, Tsukasa Saito, Jun Sawada, Akiho Minoshima, Naka Sakamoto, Kazumi Akasaka, Naoyuki Miyokawa, Ichizo Nishino, Hatsue Ishibashi-Ueda, Naoyuki Hasebe

著者情報

Shiori Takeguchi-Kikuchi
Division of Neurology, First Department of Internal Medicine, Asahikawa Medical University, Japan
Taiki Hayasaka
Division of Cardiology, First Department of Internal Medicine, Asahikawa Medical University, Japan
Takayuki Katayama
Division of Neurology, First Department of Internal Medicine, Asahikawa Medical University, Japan
Kohei Kano
Division of Neurology, First Department of Internal Medicine, Asahikawa Medical University, Japan
Kae Takahashi
Division of Neurology, First Department of Internal Medicine, Asahikawa Medical University, Japan
Tsukasa Saito
Division of Neurology, First Department of Internal Medicine, Asahikawa Medical University, Japan
Jun Sawada
Division of Neurology, First Department of Internal Medicine, Asahikawa Medical University, Japan
Akiho Minoshima
Division of Cardiology, First Department of Internal Medicine, Asahikawa Medical University, Japan
Naka Sakamoto
Division of Cardiology, First Department of Internal Medicine, Asahikawa Medical University, Japan
Kazumi Akasaka
Division of Cardiology, First Department of Internal Medicine, Asahikawa Medical University, Japan
Naoyuki Miyokawa
Department of Clinical Pathology, Asahikawa Medical University, Japan
Ichizo Nishino
Department of Neuromuscular Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Japan
Hatsue Ishibashi-Ueda
Department of Pathology, National Cerebral and Cardiovascular Center, Japan
Naoyuki Hasebe
Division of Neurology, First Department of Internal Medicine, Asahikawa Medical University, Japan
Division of Cardiology, First Department of Internal Medicine, Asahikawa Medical University, Japan

キーワード: anti-signal recognition particle (SRP) antibody, necrotizing myopathy, cardiomyopathy, myocardial biopsy, positron-emission tomography (PET)

ジャーナルオープンアクセス早期公開

論文ID: 2564-18

DOI https://doi.org/10.2169/internalmedicine.2564-18

この記事には本公開記事があります。

The final version of this article is now available: Vol. 58 (2019), No. 21 pp. 3189-3194

詳細

抄録

A 69-year-old Japanese woman was admitted to our hospital with progressive muscle weakness and dysphagia. She was taking pitavastatin for dyslipidemia. Her serum creatine kinase was 6,300 U/L. Pitavastatin was stopped, but her symptoms deteriorated, and cardiac congestion appeared. A muscle biopsy showed necrotizing myopathy (NM), and anti-signal recognition particle (SRP) antibody was positive. ¹⁸F-fluorodeoxyglucose-positron emission tomography showed an abnormal uptake, and magnetic resonance imaging showed abnormal gadolinium enhancement in the left ventricular wall. An endomyocardial biopsy revealed inflammatory cardiomyopathy. Steroid, tacrolimus, and intravenous immunoglobulins were effective against the symptoms. This is the first case of biopsy-proven secondary cardiomyopathy due to anti-SRP-positive NM.

責任著者(Corresponding author)

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