T-cell Lymphoma Presenting Neutrophilic Inflammation in the Cerebrospinal Fluid: A Case Report

Takaaki Nakamura; Yoshiki Takai; Kimihiko Kaneko; Hiroshi Kuroda; Tatsuro Misu; Kiyotaka Asanuma; Ryoko Saito; Masashi Aoki

doi:10.2169/internalmedicine.3093-19

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引用する場合も本公開記事を引用してください。

T-cell Lymphoma Presenting Neutrophilic Inflammation in the Cerebrospinal Fluid: A Case Report

Takaaki Nakamura, Yoshiki Takai, Kimihiko Kaneko, Hiroshi Kuroda, Tatsuro Misu, Kiyotaka Asanuma, Ryoko Saito, Masashi Aoki

著者情報

キーワード: polymorphonuclear leukocyte, neuro-Behçet's disease, neuro-neutrophilic disease, interleukin-6, interleukin-8, interleukin-17

ジャーナルオープンアクセス早期公開

論文ID: 3093-19

DOI https://doi.org/10.2169/internalmedicine.3093-19

この記事には本公開記事があります。

The final version of this article is now available: Vol. 59 (2020), No. 4 pp. 573-576

詳細

抄録

A 66-year-old woman presented with upper abdominal pain and weakness in the limbs. She had bilateral uveitis and gastric ulcers. A neurological examination revealed tetraparesis and sensory disturbance in the right arm. A cerebrospinal fluid (CSF) examination showed polymorphonuclear pleocytosis with elevated pro-inflammatory cytokine levels. Magnetic resonance imaging showed brain lesions and a long spinal cord lesion. She was initially diagnosed with neuro-Behçet's disease and was treated with corticosteroids, resulting in no improvement. A gastric mucosa biopsy indicated T-cell lymphoma colocalizing with neutrophils. The cytokine-mediated neutrophilic inflammation probably caused characteristic CSF and histopathological features. It is noteworthy that T-cell lymphoma may present with CSF neutrophilic inflammation.

責任著者(Corresponding author)

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