Dapagliflozin-induced drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Followed By Acute Interstitial Nephritis (AIN): A Case Report

Tomohisa Tsuyuki; Kenta Torigoe; Masatoshi Shimizu; Hiroshi Taira; Ryosuke Sakamoto; Shinichi Abe; Sayaka Kuwatsuka; Kumiko Muta; Hiroshi Mukae; Tomoya Nishino

doi:10.2169/internalmedicine.3347-23

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Dapagliflozin-induced drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Followed By Acute Interstitial Nephritis (AIN): A Case Report

Tomohisa Tsuyuki, Kenta Torigoe, Masatoshi Shimizu, Hiroshi Taira, Ryosuke Sakamoto, Shinichi Abe, Sayaka Kuwatsuka, Kumiko Muta, Hiroshi Mukae, Tomoya Nishino

著者情報

キーワード: Sodium-glucose cotransporter 2 inhibitors, Acute interstitial nephritis, Drug reaction with eosinophilia and systemic symptoms, Drug hypersensitivity

ジャーナルオープンアクセス早期公開

論文ID: 3347-23

DOI https://doi.org/10.2169/internalmedicine.3347-23

この記事には本公開記事があります。

The final version of this article is now available: Vol. 63 (2024), No. 23 pp. 3203-3208

詳細

抄録

A 78-year-old male was admitted to the hospital with acute renal failure and generalized erythema after starting dapagliflozin 10 mg/day for chronic kidney disease (CKD). A skin biopsy revealed superficial perivascular dermatitis with eosinophils. A renal biopsy revealed lymphocytic and eosinophilic infiltration of the interstitium, and focal tubulitis. The patient was diagnosed with a dapagliflozin-induced drug reaction with eosinophilia and systemic symptoms (DRESS), followed by acute interstitial nephritis (AIN), and prednisolone therapy was therefore initiated. The patient's renal function improved, and erythema disappeared. To our knowledge, this is the first report of DRESS caused by dapagliflozin, and the patient was successfully treated with prednisolone.

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