Cisplatin-induced Severe Renal Salt-wasting Syndrome Complicated with Hypovolemic Shock and Various Electrolyte Abnormalities in a Patient with Thymoma: A Case Report

Takatsune Hosoya; Takeshi Masuda; Kiyofumi Shimoji; Kakuhiro Yamaguchi; Shinjiro Sakamoto; Yasushi Horimasu; Taku Nakashima; Hiroshi Iwamoto; Hironobu Hamada; Noboru Hattori

doi:10.2169/internalmedicine.5218-24

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Cisplatin-induced Severe Renal Salt-wasting Syndrome Complicated with Hypovolemic Shock and Various Electrolyte Abnormalities in a Patient with Thymoma: A Case Report

Takatsune Hosoya, Takeshi Masuda, Kiyofumi Shimoji, Kakuhiro Yamaguchi, Shinjiro Sakamoto, Yasushi Horimasu, Taku Nakashima, Hiroshi Iwamoto, Hironobu Hamada, Noboru Hattori

著者情報

キーワード: renal salt-wasting syndrome, hypovolemic shock, electrolyte abnormality, cisplatin, thymoma, inappropriate secretion of antidiuretic hormone

ジャーナルオープンアクセス早期公開

論文ID: 5218-24

DOI https://doi.org/10.2169/internalmedicine.5218-24

この記事には本公開記事があります。

The final version of this article is now available: Vol. 64 (2025), No. 22 pp. 3272-3278

詳細

抄録

Renal salt-wasting syndrome (RSWS) induced by cisplatin causes hyponatremia and dehydration. A 75-year-old woman with thymoma underwent cisplatin chemotherapy. She presented with hypovolemic shock, seizures, and impaired consciousness (Japan Coma Scale II-30) with a decreased serum sodium level of 116 mmol/L on day 9. In addition, the patient had hypokalemia, hypomagnesemia, hypocalcemia, and hypophosphatemia. We herein describe the first reported case of RSWS complicated by hypovolemic shock. This is the second reported case with multiple electrolyte abnormalities. Thus, we should recognize that severe RSWS with hypovolemic shock and multiple electrolyte abnormalities can occur in patients undergoing cisplatin treatment.

責任著者(Corresponding author)

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